At Liminal, we have developed a strategy to build a broader portfolio of novel small molecule compounds over time and explore opportunities for collaboration in our small molecule development programs.
Our Small Molecule Pipeline
Our most advanced preclinical program is for the development of a selective GPR84 antagonist drug product candidate designed to treat inflammation and/or fibrosis in several different therapeutic categories. We believe that the GPR84 receptor could be an important biological target in a number of therapeutic areas of interest. GPR84 is broadly expressed and may play an interesting role in the relationship between inflammation, obesity and diabetes. Our preclinical research indicates a potential role for antagonism of GPR84 in the reduction of fibrosis in several diseases, including kidney disease and Non-Alcoholic Steatohepatitis, or NASH.
In addition to GRP84, we intend to develop a novel, selective OXER1 antagonist candidate. OXER1 is a G protein-coupled receptor (GPCR that is highly selective for 5-oxo-ETE, believed to be one of the most potent human eosinophil chemo-attractants. Eosinophils play a key role in Type 2 inflammation-driven diseases, including respiratory diseases and gastrointestinal diseases. Our GPR84 antagonist and OXER1 antagonist R&D programs are currently both at the pre-clinical research stage.
Advancing the clinical development of our small molecule pipeline candidates
Our goal is to leverage our drug discovery platform and to develop distinctive novel small molecule therapeutics to treat the complex biology of inflammatory, metabolic and fibrotic disease to address significant unmet needs.
The key activities to achieve this goal include:
- Selecting a preclinical candidate for our GRP84 antagonist program for further development;
- Selecting a preclinical candidate for our OXER1 antagonist program for further development;
- Actively pursuing opportunities to monetize non-core assets and to streamline costs overall